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Search Results for " 20 hete "

12

Compounds

Cat No. Product Name Synonyms Targets
T14021 20-HETE 20-hydroxy Arachidonic Acid Others
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ...
T83400 20-HETE inhibitor-1
20-HETE Inhibitor-1 (Comp 83) serves as an inhibitor of 20-HETE formation [1].
T14186 17-ODYA Alkynyl Stearic Acid Others , PROTAC Linker
17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
T11556 HET0016 Others
HET0016 is a potent and selective 20-HETE synthase inhibitor (IC50s: 17.7 nM, 12.1 nM, and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis). HET0016 also is a selective CYP450 inhibitor, w...
T37826 CAY10462 CAY10462,CTK8E8405 P450
CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less potent for 1A, 1C, and 3A CYP450 enzymes.
T72501 CYP4A11/CYP4F2-IN-1 P450
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebrovascular diseases.
T67916 CYP4A11/CYP4F2-IN-2 P450
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney an...
T13343 20-HEDE WIT 002 Others
20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist.
T35467 (±)18-HETE
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasod...
T36232 20-carboxy Arachidonic Acid
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p...
T36216 19(R)-HETE
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o...
T35855 AAA
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-...
TargetMol