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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14021 | 20-HETE | 20-hydroxy Arachidonic Acid | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... | |||
T83400 | 20-HETE inhibitor-1 | ||
20-HETE Inhibitor-1 (Comp 83) serves as an inhibitor of 20-HETE formation [1]. | |||
T14186 | 17-ODYA | Alkynyl Stearic Acid | Others , PROTAC Linker |
17-ODYA (Alkynyl Stearic Acid) is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. | |||
T11556 | HET0016 | Others | |
HET0016 is a potent and selective 20-HETE synthase inhibitor (IC50s: 17.7 nM, 12.1 nM, and 20.6 nM for recombinant CYP4A1-, CYP4A2- and CYP4A3-catalyzed 20-HETE synthesis). HET0016 also is a selective CYP450 inhibitor, w... | |||
T37826 | CAY10462 | CAY10462,CTK8E8405 | P450 |
CAY10462 (CTK8E8405) is an effective and selective inhibitor of the 20-HETE synthase CYP4A11 with an IC50 of 8.8 nM. CAY10462 exhibits nearly 200 times less potent for 1A, 1C, and 3A CYP450 enzymes. | |||
T72501 | CYP4A11/CYP4F2-IN-1 | P450 | |
CYP4A11/CYP4F2-IN-1 is a cytochrome P450 (CYP) 4A11 and CYP4F2 inhibitor. CYP4A11/CYP4F2-IN-1 can be used to study kidney diseases and cardiovascular and cerebrovascular diseases. | |||
T67916 | CYP4A11/CYP4F2-IN-2 | P450 | |
CYP4A11/CYP4F2-IN-2 is a potent and orally active dual inhibitor of cytochrome P450 (CYP) 4A11 and CYP4F2, with IC50 values of 140 nM and 40 nM, respectively. CYP4A11/CYP4F2-IN-2 can be extracted from liver and kidney an... | |||
T13343 | 20-HEDE | WIT 002 | Others |
20-HEDE (WIT 002) is a 20-hydroxyeicosatetraenoic acid (20-HETE) antagonist. | |||
T35467 | (±)18-HETE | ||
(±)18-HETE is the racemic version of a cytochrome P450 (CYP450) metabolite of arachidonic acid. When formed by the CYP2E1 isoform, 18-HETE is comprised 100% of the (R) isomer. 18(R)-HETE dose-dependently stimulates vasod... | |||
T36232 | 20-carboxy Arachidonic Acid | ||
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p... | |||
T36216 | 19(R)-HETE | ||
19-HETE is one of the major cytochrome P450 (CYP450) metabolites of arachidonic acid that is released from the kidney in response to angiotensin II. When formed by the CYP2E1 isoform, 19-HETE is composed of 70% and 30% o... | |||
T35855 | AAA | ||
AAA is an antagonist of G protein-coupled receptor 75 (GPR75).1It increases basal GPR75 protein levels and inhibits 20-HETE-induced reductions in GPR75 protein levels in PC3 cells. AAA (5 and 10 μM) also reduces 20-HETE-... |